Precise Release of Synergistic Radiosensitizers from Microneedles to Enhance X-Ray Radiotherapy for the Treatment of Skin Squamous Cell Carcinoma

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Project title

Code/計畫編號

MOST111-2221-E019-011

Translated Name/計畫中文名

微針精準釋放輻射增敏劑協同X光放射療法用於皮膚鱗狀上皮細胞癌之治療

Project Coordinator/計畫主持人

Yi-Cheng Huang

Funding Organization/主管機關

National Science and Technology Council

Department/Unit

Department of Food Science

Website

https://www.grb.gov.tw/search/planDetail?id=14521907

Year

2022

Start date/計畫起

01-08-2022

Expected Completion/計畫迄

31-07-2023

Bugetid/研究經費

1276千元

ResearchField/研究領域

醫學工程

近年來，透過微針給藥的經皮傳輸系統為皮膚癌的治療注入新的曙光。本計畫運用天然高分子石蓴多醣的物化及機械特性製備微針，結合薑黃素的抗癌活性和及輻射增敏效果，製備具有靶向特性的薑黃素傳輸載體，透過經皮遞送系統來治療皮膚鱗狀細胞癌，期望減少化療藥物及放射劑量的使用，提高皮膚癌的治療成效，有效地將天然資源做最佳的利用並提供皮膚癌治療的策略，達到新穎生物醫學材料開發、增進全民健康、發展海洋經濟及維護海洋環境等多重目的。

Keyword(s)

石蓴多醣
薑黃素
可溶性微針
皮膚鱗狀細胞癌
放射療法
ulvan
curcumin
dissolvable microneedles
skin squamous cell carcinoma
synergistic therapy
radiation therapy

DSpace CRIS

Precise Release of Synergistic Radiosensitizers from Microneedles to Enhance X-Ray Radiotherapy for the Treatment of Skin Squamous Cell Carcinoma

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