Precise Release of Curcumin from Dissolving Ulvan Microneedle for Chemical Synergistic Radiotherapy in the Treatment of Skin Squamous Cell Carcinoma

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Project title

Code/計畫編號

NSTC112-2221-E019-059

Translated Name/計畫中文名

可溶性石蓴多醣微針精確釋放薑黃素協同放射療法治療皮膚鱗狀細胞癌

Project Coordinator/計畫主持人

Yi-Cheng Huang

Funding Organization/主管機關

National Science and Technology Council

Department/Unit

Department of Food Science

Website

https://www.grb.gov.tw/search/planDetail?id=15421508

Year

2023

Start date/計畫起

01-08-2023

Expected Completion/計畫迄

31-07-2024

Bugetid/研究經費

1134千元

ResearchField/研究領域

醫學工程

近年來，透過微針給藥的經皮傳輸系統為皮膚癌的治療注入新的曙光。本計畫運用天然高分子石蓴多醣的物化及機械特性製備微針，結合薑黃素的抗癌活性和及輻射增敏效果，製備具有靶向特性的薑黃素傳輸載體，透過經皮遞送系統來治療皮膚鱗狀細胞癌，期望減少化療藥物及放射劑量的使用，提高皮膚癌的治療成效，有效地將天然資源做最佳的利用並提供皮膚癌治療的策略，達到新穎生物醫學材料開發、增進全民健康、發展海洋經濟及維護海洋環境等多重目的。

Keyword(s)

石蓴多醣
薑黃素
可溶性微針
皮膚鱗狀細胞癌
協同治療
放射療法
ulvan
curcumin
dissolvable microneedles
skin squamous cell carcinoma
synergistic therapy
radiation therapy

DSpace CRIS

Precise Release of Curcumin from Dissolving Ulvan Microneedle for Chemical Synergistic Radiotherapy in the Treatment of Skin Squamous Cell Carcinoma

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