http://scholars.ntou.edu.tw/handle/123456789/19116
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Nain, Amit | en_US |
dc.contributor.author | Huang, Hao-Hsin | en_US |
dc.contributor.author | Chevrier, Daniel M. | en_US |
dc.contributor.author | Tseng, Yu-Ting | en_US |
dc.contributor.author | Sangili, Arumugam | en_US |
dc.contributor.author | Lin, Yu-Feng | en_US |
dc.contributor.author | Huang, Yu-Fen | en_US |
dc.contributor.author | Chang, Lung | en_US |
dc.contributor.author | Chang, Fu-Chieh | en_US |
dc.contributor.author | Huang, Chih-Ching | en_US |
dc.contributor.author | Tseng, Fan-Gang | en_US |
dc.contributor.author | Chang, Huan-Tsung | en_US |
dc.date.accessioned | 2021-12-10T00:28:17Z | - |
dc.date.available | 2021-12-10T00:28:17Z | - |
dc.date.issued | 2021-11-18 | - |
dc.identifier.issn | 2040-3364 | - |
dc.identifier.uri | http://scholars.ntou.edu.tw/handle/123456789/19116 | - |
dc.description.abstract | We report a one-pot facile synthesis of highly photoresponsive bovine serum albumin (BSA) templated bismuth-copper sulfide nanocomposites (BSA-BiZ/CuxS NCs, where BiZ represents in situ formed Bi2S3 and bismuth oxysulfides (BOS)). As-formed surface vacancies and BiZ/CuxS heterojunctions impart superior catalytic, photodynamic and photothermal properties. Upon near-infrared (NIR) irradiation, the BSA-BiZ/CuxS NCs exhibit broad-spectrum antibacterial activity, not only against standard multidrug-resistant (MDR) bacterial strains but also against clinically isolated MDR bacteria and their associated biofilms. The minimum inhibitory concentration of BSA-BiZ/CuxS NCs is 14-fold lower than that of BSA-CuxS NCs because their multiple heterojunctions and vacancies facilitated an amplified phototherapeutic response. As-prepared BSA-BiZ/CuxS NCs exhibited substantial biofilm inhibition (90%) and eradication (>75%) efficiency under NIR irradiation. Furthermore, MRSA-infected diabetic mice were immensely treated with BSA-BiZ/CuxS NCs coupled with NIR irradiation by destroying the mature biofilm on the wound site, which accelerated the wound healing process via collagen synthesis and epithelialization. We demonstrate that BSA-BiZ/CuxS NCs with superior antimicrobial activity and high biocompatibility hold great potential as an effective photosensitive agent for the treatment of biofilm-associated infections. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ROYAL SOC CHEMISTRY | en_US |
dc.relation.ispartof | NANOSCALE | en_US |
dc.subject | PHOTOTHERMAL ABLATION | en_US |
dc.subject | OXYGEN | en_US |
dc.subject | ANTIBACTERIAL | en_US |
dc.subject | NANOPARTICLES | en_US |
dc.subject | NANOCRYSTALS | en_US |
dc.subject | MECHANISMS | en_US |
dc.subject | GROWTH | en_US |
dc.subject | CU2S | en_US |
dc.title | Catalytic and photoresponsive BiZ/CuxS heterojunctions with surface vacancies for the treatment of multidrug-resistant clinical biofilm-associated infections | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.1039/d1nr06358h | - |
dc.identifier.isi | WOS:000714391100001 | - |
dc.relation.journalvolume | 13 | en_US |
dc.relation.journalissue | 44 | en_US |
dc.relation.pages | 18632-18646 | en_US |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
crisitem.author.dept | College of Life Sciences | - |
crisitem.author.dept | Department of Bioscience and Biotechnology | - |
crisitem.author.dept | National Taiwan Ocean University,NTOU | - |
crisitem.author.dept | Center of Excellence for the Oceans | - |
crisitem.author.orcid | 0000-0002-0363-1129 | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | College of Life Sciences | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
顯示於: | 生命科學暨生物科技學系 03 GOOD HEALTH AND WELL-BEING |
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