In-situ formation of 2H phase MoS2/cerium-zirconium oxide nanohybrid for potential electrochemical detection of an anticancer drug flutamide

Abstract

The developing field of sensors is highly motivated and attracted by two-dimensional transition metal dichalcogenides (TMDs) with transition metal oxide integration. Initially, molybdenum disulfide (MoS2), one among the TMDs with cerium-zirconium oxide (CZO), was one-pot synthesized via hydrothermal method for sensing flutamide (FLD). The as-synthesized hybrid nanocomposite was characterized to understand their physical and chemical presence. MoS2-CZO was well assigned with crystalline nature observed from X-ray powder diffraction and X-ray photoelectron spectroscopy. High-resolution transmission electron microscopy confirms the irregularly arranged nanoparticles wrapped with MoS2 sheets. The wide surface area with more electroactive sites has provided higher conductance of the MoS2-CZO/glassy carbon electrode. The limit of detection was 0.005 mu M with a linear range of 0.019 mu M to 668.5 mu M, sensitivity 0.353 mu A mu M-1 cm(-2). The practical feasibility was analyzed with human urine and river water samples, whereas the obtained results showed excellent FLD detection. The fabricated MoS2-CZO with all these distinguished analyses will be an outbreak in the field of electrochemical sensors. (C) 2021 Elsevier Ltd. All rights reserved.