The Significance of β-glucan Binding Protein in Executing Immunity in Invertebrate

Abstract

Invertebrate, which lack adaptive immune system, have developed defence mechanisms that respond against antigens present on the surface of potential pathogens. The defence mechanisms of invertebrate depend on the innate immunesystem that is activated when pattern recognition proteins (PRPs) recognize the signature molecules of microbes which, in turn, activate cellular and humoral effector mechanisms to destroy invading pathogens. β-1,3-glucan binding protein (βGBP) is a crucial pattern recognition protein, that distinctively binds with β-1,3-glucan (βG), a surface marker of fungal cell wall. βGBP triggers innate immunity by activating prophenoloxidase cascade, and eliminate the pathogenic invasion. This review analyses the functional role of βGBP in the specific recognition of carbohydrate containing molecule βG present at the surface of bacteria and fungi.無脊椎動物缺乏適應性免疫系統，發展出在病原面上的病原扺抗。無脊椎動物的病原扺抗機制是依賴先天性免疫，當病源辨識蛋白辨識病原信號分子，啟動細胞性與体液性作用機制，破壞入侵病源。葡聚醣結合蛋白為重要的辨識蛋白，明顯結合真菌表面上的葡聚醣，介由活化原酚氧化酶，啟動先天性免疫，消滅入侵病原。本篇回顧論文解析辨識蛋白在辨識細菌或真菌細胞表面醣類的機能角色。