http://scholars.ntou.edu.tw/handle/123456789/21472
Title: | A combination of Lactobacillus mali APS1 and dieting improved the efficacy of obesity treatment via manipulating gut microbiome in mice | Authors: | Yung-Tsung Chen Ning-Sun Yang Yu-Chun Lin Shang-Tse Ho Kuan-Yi Li Jin-Seng Lin Je-Ruei Liu Ming-Ju Chen |
Issue Date: | Apr-2018 | Publisher: | NATURE RESEARCH | Journal Issue: | 8 | Source: | SCIENTIFIC REPORTS | Abstract: | The difficulty of long-term management has produced a high rate of failure for obesity patients. Therefore, improving the efficacy of current obesity treatment is a significant goal. We hypothesized that combining a probiotic Lactobacillus mali APS1 intervention with dieting could improve the efficacy of obesity and hepatic steatosis treatment compared to dieting alone. Mice were fed a high-fat diet for 6 weeks and then treated with: saline + normal diet and APS1 + normal diet (NDAPS1) for 3 weeks. NDAPS1 accelerated body weight loss and reduced caloric intake and fat accumulation. The fecal microbiome showed that accelerating weight loss by NDAPS1 resulted in restoring intestinal microbiota toward a pre-obese state, with alteration of specific changes in the obesity-associated bacteria. APS1 manipulated the gut microbiome’s obesity-associated metabolites, followed by regulation of lipid metabolism, enhancement of energy expenditure and inhibition of appetite. The specific hepatic metabolites induced by the APS1-manipulated gut microbiome also contributed to the amelioration of hepatic steatosis. Our results highlighted a possible microbiome and metabolome that contributed to accelerating weight loss following treatment with a combination of APS1 and dieting and suggested that probiotics could serve as a potential therapy for modulating physiological function and downstream of the microbiota. |
URI: | http://scholars.ntou.edu.tw/handle/123456789/21472 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-018-23844-y |
Appears in Collections: | 食品科學系 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.