Preparation of Molecular Aptamer Conjugated Nanodots for Detection of Tumor Markers and Drug Development.

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Project title

Code/計畫編號

NSC97-2113-M019-001-MY2

Translated Name/計畫中文名

分子適合體修飾微奈米材料於腫瘤標記的偵測與藥物開發

Project Coordinator/計畫主持人

Chih-Ching Huang

Funding Organization/主管機關

National Science and Technology Council

Department/Unit

Department of Bioscience and Biotechnology

Website

https://www.grb.gov.tw/search/planDetail?id=1711524

Year

2008

Start date/計畫起

01-08-2008

Expected Completion/計畫迄

31-07-2008

Bugetid/研究經費

2233千元

ResearchField/研究領域

醫學工程

"本計畫之目標是利用分子適合體（aptamer）修飾的微奈米粒子（nanodots）偵測與追蹤腫瘤細胞內蛋白質變化。分子適合體修飾的微奈米粒子後作為腫瘤蛋白質的研究。計畫將著重於：(1) 合成與修飾多功能微奈米粒子； (2) 分子適合體之微奈米粒子應用於檢測腫瘤蛋白與研究端粒脢酵素；(3) 分子適合體之微奈米粒子於抗凝血藥物研究。" "The goal of this proposal is synthesis of highly luminescent nonodots and preparation of aptamer conjugated nanodots for detection of tumor markers and tumor-cells imaging. The aptamers conjugated nanodots will be applied to obtain molecular profiles of tumor cells. Our proposed research will capitalize on: (1) Synthesis and modification of multifunctional nanodot materials; (2) Application of aptamer modified nanodots to detect tumor markers, and to investigate the activity of telomerease; (3) Study of aptamer modified nanodots in anticoagulation therapy."

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Preparation of Molecular Aptamer Conjugated Nanodots for Detection of Tumor Markers and Drug Development.

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