Studies of Chemoenzymatic Synthesis of Magnolol and Its Anti-Inflammatory Activities

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Project title

Code/計畫編號

NSC91-2113-M019-001

Translated Name/計畫中文名

化學與酵素合成厚朴酚及其抗炎活性探討

Project Coordinator/計畫主持人

Yeuk-Chuen Liu

Funding Organization/主管機關

National Science and Technology Council

Department/Unit

Department of Food Science

Website

https://www.grb.gov.tw/search/planDetail?id=731990

Year

2002

Start date/計畫起

01-08-2002

Expected Completion/計畫迄

01-07-2003

Bugetid/研究經費

426千元

ResearchField/研究領域

藥學

本研究探討利用仿生方法進行oxidative phenolic coupling合成biphenyl neolignan derivatives。探討不同反應條件(不同來源的peroxidases酵素、pH、有機溶液、及基質、過氧化氫與酵素比例)對產物及產率的影響後發現，不同的酚結構對反應有不同的影響，以horseradish peroxidase催化4-allylphenol的oxidative phenolic coupling可得較高產率之dimer，為了減少更改不同反應條件後可得magnolol。 Utilization of peroxidases for the biomimic synthesis of neolignan derivative has been studied. Different reaction conditions have been tried, such as different pH, buffers, co-solvents, and the addition rate of hydrogen peroxide. The present studies found that horseradish peroxidase gave higher yield than other peroxidases for the oxidative phenolic coupling of 4-allylphenol. Under the optimum condition, 4-allylphenol dimer, magnolol, can be obtained in desired yield.

Keyword(s)

過氧化酵素
氧化性酚類耦合
酵素合成
化學合成
厚朴酚
仿生合成
Peroxidase
Oxidative phenolic coupling
biomicmic synthesis
Enzymatic synthesis
Chemical synthesis
Magnolol
Biomimetics synthesis

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Studies of Chemoenzymatic Synthesis of Magnolol and Its Anti-Inflammatory Activities

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