Studies of Chemoenzymatic Synthesis of Magnolol and Its Anti-Inflammatory Activities

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基本資料

Project title

Code/計畫編號

NSC91-2113-M019-001

Translated Name/計畫中文名

化學與酵素合成厚朴酚及其抗炎活性探討

Project Coordinator/計畫主持人

Yeuk-Chuen Liu

Funding Organization/主管機關

National Science and Technology Council

Department/Unit

Department of Food Science

Website

https://www.grb.gov.tw/search/planDetail?id=731990

Year

2002

Start date/計畫起

01-08-2002

Expected Completion/計畫迄

01-07-2003

Bugetid/研究經費

426千元

ResearchField/研究領域

藥學

本研究探討利用仿生方法進行oxidative phenolic coupling合成biphenyl neolignan derivatives。探討不同反應條件(不同來源的peroxidases酵素、pH、有機溶液、及基質、過氧化氫與酵素比例)對產物及產率的影響後發現，不同的酚結構對反應有不同的影響，以horseradish peroxidase催化4-allylphenol的oxidative phenolic coupling可得較高產率之dimer，為了減少更改不同反應條件後可得magnolol。 Utilization of peroxidases for the biomimic synthesis of neolignan derivative has been studied. Different reaction conditions have been tried, such as different pH, buffers, co-solvents, and the addition rate of hydrogen peroxide. The present studies found that horseradish peroxidase gave higher yield than other peroxidases for the oxidative phenolic coupling of 4-allylphenol. Under the optimum condition, 4-allylphenol dimer, magnolol, can be obtained in desired yield.

Keyword(s)

過氧化酵素
氧化性酚類耦合
酵素合成
化學合成
厚朴酚
仿生合成
Peroxidase
Oxidative phenolic coupling
biomicmic synthesis
Enzymatic synthesis
Chemical synthesis
Magnolol
Biomimetics synthesis

DSpace CRIS

Studies of Chemoenzymatic Synthesis of Magnolol and Its Anti-Inflammatory Activities

基本資料

Description