Dietary Taurine Reduces Oxidized Fish Oil and Vitamin A Induced Toxicity in Male Wistar Rats

Abstract

Attempts are made to investigate the effects of taurine and oxidized fish oil on vitamin A. Thirty male wistar rats were divided five groups of male Wistar rats were fed a mega dose (50,000 IU) of retinyl palmitate either with or without supplement of taurine and oxidized fish oil at the same time for 6 weeks. After , 4 and 6 weeks of treatment, each group of six rats were killed and examined. It was found that oxidized fish oil significantly elevated the symptoms of vitamin A, which includes the decrease of body weight and the concentration of glutathione (GSH) in liver and increase the ratios of liver and kidney weight to body weight, the activities of AST, ALT and ALP in plasma, the level of TBARS in liver and plasma, the levels of BUN and creatinine in the plasma, the level of vitamin A in the plasma (P<0.05). However, taurine significantly ameliorated the toxicity of vitamin A with oxidized fish oil. It increases body weight and reduces the concentration of WBC and HCT in blood, the levels of vitamin A in the liver and kidney, the level of TBARS in liver, the ratios of liver and kidney weight to body weight, the activities of AST, ALT and ALP in plasma, and the levels of cholesterol, triglyceride, calcium and phosphorus in plasma (P<0.05). Therefore, oxidized fish oil elevated the toxicity of vitamin A, while taurine prevented the toxicity of vitamin A and oxidized fish oil.