http://scholars.ntou.edu.tw/handle/123456789/20346
標題: | Blue Mussel (Mytilus edulis) Water Extract Ameliorates Inflammatory Responses and Oxidative Stress on Osteoarthritis in Obese Rats | 作者: | Chang, Heng-Wei Sudirman, Sabri Yen, Yu-Wen Mao, Chien-Feng Ong, Alan Darmasaputra Kong, Zwe-Ling |
關鍵字: | ARTICULAR-CARTILAGE;HISTOPATHOLOGY;GLYCOPROTEIN;PATHOGENESIS;MECHANISM;BEHAVIOR | 公開日期: | 十一月-2020 | 出版社: | DOVE MEDICAL PRESS LTD | 卷: | 13 | 起(迄)頁: | 1109-1119 | 來源出版物: | J PAIN RES | 摘要: | Purpose: To investigate the effects of Mytilus edulis water extract (MWE) on an anterior cruciate ligament transection and a partial medial meniscectomy surgery to induced osteoarthritis (OA) with the high-fat diet (HFD)-induced obese rats. Methods: The male Sprague-Dawley rats were fed with HFD for 4 weeks before surgery. The OA rats were orally administered with MWE (108.5, 217.0, and 542.5 mg/kg) for 6 weeks. Results: The administration of MWE affected weight loss, triglycerides content, and total cholesterol level. MWE also enhanced the activity of superoxide dismutase and decreased lipid peroxidation degree. Moreover, MWE reduced proinflammatory cytokines level, alleviated inflammation and swelling of the osteoarthritic knee, and reduced loss of proteoglycan in articular cartilage tissue. Conclusion: MWE suppressed proinflammatory mediators and attenuated the cartilage degradation and pain in osteoarthritis rats under obesity condition. Therefore, MWE has the potential to act as an alternative for osteoarthritis treatment. |
URI: | http://scholars.ntou.edu.tw/handle/123456789/20346 | ISSN: | 1178-7090 | DOI: | 10.2147/JPR.S244372 |
顯示於: | 食品科學系 02 ZERO HUNGER 03 GOOD HEALTH AND WELL-BEING |
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