http://scholars.ntou.edu.tw/handle/123456789/20368
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Yu, Jiantao | - |
dc.contributor.author | Lin, Yu-Hsin | - |
dc.contributor.author | Yang, Lingyan | - |
dc.contributor.author | Huang, Chih-Ching | - |
dc.contributor.author | Chen, Liliang | - |
dc.contributor.author | Wang, Wen-Cheng | - |
dc.contributor.author | Chen, Guan-Wen | - |
dc.contributor.author | Yan, Junyan | - |
dc.contributor.author | Sawettanun, Saranta | - |
dc.contributor.author | Lin, Chia-Hua | - |
dc.date.accessioned | 2022-02-17T03:53:09Z | - |
dc.date.available | 2022-02-17T03:53:09Z | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 2192-2640 | - |
dc.identifier.uri | http://scholars.ntou.edu.tw/handle/123456789/20368 | - |
dc.description.abstract | Despite tremendous efforts toward developing novel near-infrared (NIR)-absorbing nanomaterials, improvement in therapeutic efficiency remains a formidable challenge in photothermal cancer therapy. This study aims to synthesize a specific peptide conjugated polydopamine-modified reduced graphene oxide (pDA/rGO) nanocomposite that promotes the bystander effect to facilitate cancer treatment using NIR-activated photothermal therapy. To prepare a nanoplatform capable of promoting the bystander effect in cancer cells, we immobilized antiarrhythmic peptide 10 (AAP10) on the surface of dopamine-modified rGO (AAP10-pDA/rGO). Our AAP10-pDA/rGO could promote the bystander effect by increasing the expression of connexin 43 protein in MCF-7 breast-cancer cells. Because of its tremendous ability to absorb NIR absorption, AAP10-pDA/rGO offers a high photothermal effect under NIR irradiation. This leads to a massive death of MCF-7 cells via the bystander effect. Using tumor-bearing mice as the model, it is found that NIR radiation effectively ablates breast tumor in the presence of AAP10-pDA/rGO and inhibits tumor growth by approximate to 100%. Therefore, this research integrates the bystander and photothermal effects into a single nanoplatform in order to facilitate an efficient photothermal therapy. Furthermore, our AAP10-pDA/rGO, which exhibits both hyperthermia and the bystander effect, can prevent breast-cancer recurrence and, therefore, has great potential for future clinical and research applications. | - |
dc.language.iso | en_US | - |
dc.publisher | WILEY | - |
dc.relation.ispartof | ADV HEALTHC MATER | - |
dc.subject | CANCER-CELLS | - |
dc.subject | GRAPHITE OXIDE | - |
dc.subject | STEM-CELLS | - |
dc.subject | REDUCTION | - |
dc.subject | DELIVERY | - |
dc.subject | NANOPARTICLES | - |
dc.subject | POLYDOPAMINE | - |
dc.subject | HYPERTHERMIA | - |
dc.subject | GENOTOXICITY | - |
dc.subject | COMPOSITES | - |
dc.title | Improved Anticancer Photothermal Therapy Using the Bystander Effect Enhanced by Antiarrhythmic Peptide Conjugated Dopamine-Modified Reduced Graphene Oxide Nanocomposite | - |
dc.type | journal article | - |
dc.identifier.doi | 10.1002/adhm.201600804 | - |
dc.identifier.isi | WOS:000393590400009 | - |
dc.identifier.url | <Go to ISI>://WOS:000393590400009 | - |
dc.relation.journalvolume | 6 | - |
dc.relation.journalissue | 2 | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
crisitem.author.dept | College of Life Sciences | - |
crisitem.author.dept | Department of Bioscience and Biotechnology | - |
crisitem.author.dept | National Taiwan Ocean University,NTOU | - |
crisitem.author.dept | Center of Excellence for the Oceans | - |
crisitem.author.dept | College of Life Sciences | - |
crisitem.author.dept | Department of Food Science | - |
crisitem.author.dept | National Taiwan Ocean University,NTOU | - |
crisitem.author.orcid | 0000-0002-0363-1129 | - |
crisitem.author.orcid | 0000-0002-3435-0725 | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | College of Life Sciences | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | College of Life Sciences | - |
顯示於: | 生命科學暨生物科技學系 食品科學系 03 GOOD HEALTH AND WELL-BEING |
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