Citric acid crosslinked sphingan WL gum hydrogel films supported ciprofloxacin for potential wound dressing application

Abstract

Sphingan WL gum (WL), a kind of exopolysaccharides, is produced by Sphingomonas sp. WG. In this study, citric acid (CA) crosslinked WL hydrogel films were firstly developed for potential wound dressing application. ATRFTIR and TG results suggested the occurrence of esterification crosslinking. SEM analysis showed that this aided covalent crosslinking could prevent their porous structures from collapsing when swelling. Due to the deprotonation of carboxyl groups, the water absorption capacity of WL-CA hydrogel films increased with the increase of pH (maximum swelling ratio = 38 g/g). The covalent crosslinked swollen WL-CA hydrogels exhibited certain hydrolytic stability, high porosity (> 60%), moderate tissue adhesion, and good rheological property (G ' > G '', G ' up to 2 kPa). WL-CA-CIP hydrogel films loaded with antibiotic ciprofloxacin (CIP) showed sustained drug release properties, long-lasting antibacterial activity, and superior biocompatibility. All the results indicated that WLbased hydrogels were potential candidates for wound dressing applications.