http://scholars.ntou.edu.tw/handle/123456789/24615
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Huang, Tse-Hung | en_US |
dc.contributor.author | Liu, Bang-Hung | en_US |
dc.contributor.author | Hsu, Chia-Hui | en_US |
dc.contributor.author | Wu, Chang-Jer | en_US |
dc.contributor.author | Liao, Kuang-Wen | en_US |
dc.contributor.author | Lin, Chen-Si | en_US |
dc.contributor.author | Chan, Yi-Lin | en_US |
dc.date.accessioned | 2024-03-05T07:47:49Z | - |
dc.date.available | 2024-03-05T07:47:49Z | - |
dc.date.issued | 2023/12/1 | - |
dc.identifier.uri | http://scholars.ntou.edu.tw/handle/123456789/24615 | - |
dc.description.abstract | Osteoarthritis (OA) is a progressive disease that causes pain, stiffness, and inflammation in the affected joints. Currently, there are no effective treatments for preventing the worst outcomes, such as synovitis or cartilage degradation. Sarcodia montagneana and Corbicula fluminea are common species found in the ocean or in freshwater areas. Their extracts are demonstrated to possess both antioxidative and anti-inflammatory functions. This study aimed to investigate the synergistic effects of the extracts of Sarcodia montagneana (SME) and Corbicula fluminea (FCE) on reducing local and systemic inflammation, as well as their efficacy in OA symptom relief. An in vitro monocytic LPS-treated THP-1 cell model and in vivo MIA-induced mouse OA model were applied, and the results showed that the combinatory usage of SME and FCE effectively suppressed IFN-gamma and TNF-alpha production when THP-1 cells were treated with LPS. SME and FCE also significantly decreased the systemic TNF-alpha level and joint swelling and prevented the loss of proteoglycan in the cartilage within the joints of OA mice. The data shown here provide a potential solution for the treatment of osteoarthritis. | en_US |
dc.language.iso | English | en_US |
dc.publisher | MDPI | en_US |
dc.relation.ispartof | ANTIOXIDANTS | en_US |
dc.subject | osteoarthritis | en_US |
dc.subject | Sarcodia montagneana | en_US |
dc.subject | Corbicula fluminea | en_US |
dc.subject | MIA-induced mouse model | en_US |
dc.subject | tumor necrosis factor-alpha | en_US |
dc.title | The Synergistic Effects of <i>Corbicula fluminea</i> and <i>Sarcodia montagneana</i> on Alleviating Systemic Inflammation and Osteoarthritis Progression | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.3390/antiox12122068 | - |
dc.identifier.isi | WOS:001136171700001 | - |
dc.relation.journalvolume | 12 | en_US |
dc.relation.journalissue | 12 | en_US |
dc.identifier.eissn | 2076-3921 | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.languageiso639-1 | English | - |
crisitem.author.dept | College of Life Sciences | - |
crisitem.author.dept | Department of Food Science | - |
crisitem.author.dept | National Taiwan Ocean University,NTOU | - |
crisitem.author.dept | Institute of Food Safety and Risk Management | - |
crisitem.author.dept | Bachelor Degree Program in Marine Biotechnology | - |
crisitem.author.dept | Center of Excellence for the Oceans | - |
crisitem.author.dept | Doctoral Degree Program in Marine Biotechnology | - |
crisitem.author.dept | Master Program of Food Satfety Management | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | College of Life Sciences | - |
crisitem.author.parentorg | College of Life Sciences | - |
crisitem.author.parentorg | College of Life Sciences | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | College of Life Sciences | - |
crisitem.author.parentorg | College of Life Sciences | - |
顯示於: | 食品科學系 |
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