http://scholars.ntou.edu.tw/handle/123456789/24699
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chung, Tze-Wen | en_US |
dc.contributor.author | Cheng, Ching-Lin | en_US |
dc.contributor.author | Liu, Yun-Huan | en_US |
dc.contributor.author | Huang, Yi-Cheng | en_US |
dc.contributor.author | Chen, Weng-Pin | en_US |
dc.contributor.author | Panda, Asit Kumar | en_US |
dc.contributor.author | Chen, Wei-Ling | en_US |
dc.date.accessioned | 2024-03-06T03:51:30Z | - |
dc.date.available | 2024-03-06T03:51:30Z | - |
dc.date.issued | 2023/11/1 | - |
dc.identifier.uri | http://scholars.ntou.edu.tw/handle/123456789/24699 | - |
dc.description.abstract | Hyaluronic acid/silk fibroin (HA/SF or HS) hydrogels with remarkable mechanical characteristics have been reported as tissue engineering biomaterials. Herein, the addition of dopamine/polydopamine (DA/PDA) to HS hydrogels to develop multifunctional HA/PDA/SF (or HDS) hydrogels for the delivery of drugs such as N-acetylL-cysteine (NAC) from nasal to brain tissue is examined. Herein, DA-dependent functions of HDS hydrogels with highly adhesive forces, photothermal response (PTR) effects generated by near infrared (NIR) irradiation, and anti-oxidative effects were demonstrated. An in-vitro study shows that the HDS/NAC hydrogels could open tight junctions in the RPMI 2650 cell line, a model cell of the nasal mucosa, as demonstrated by the decreased values of transepithelial electrical resistance (TEER) and more discrete ZO-1 staining than those for the control group. This effect was markedly enhanced by NIR irradiation of the HDS/NAC-NIR hydrogels. Compared to the results obtained using NAC solution, an in-vivo imaging study (IVIS) in rats showed an approximately nine-fold increase in the quantity of NAC delivered from the nasal cavity to the brain tissue in the span of 2 h through the PTR effect generated by the NIR irradiation of the nasal tissue and administration of the HDS/NAC hydrogels. Herein, dopamine-dependent multifunctional HDS hydrogels were studied, and the nasal administration of HDS/NACNIR hydrogels with PTR effects generated by NIR irradiation was found to have significantly enhanced NAC delivery to brain tissues. | en_US |
dc.language.iso | English | en_US |
dc.publisher | ELSEVIER | en_US |
dc.relation.ispartof | BIOMATERIALS ADVANCES | en_US |
dc.subject | Multifunctional hydrogels | en_US |
dc.subject | Adhesive | en_US |
dc.subject | Photothermal response | en_US |
dc.subject | Tight junction | en_US |
dc.subject | Nose to brain delivery | en_US |
dc.title | Dopamine-dependent functions of hyaluronic acid/dopamine/silk fibroin hydrogels that highly enhance N-acetyl-L-cysteine (NAC) delivered from nasal cavity to brain tissue through a near-infrared photothermal effect on the NAC- | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.1016/j.bioadv.2023.213615 | - |
dc.identifier.isi | WOS:001146118300001 | - |
dc.relation.journalvolume | 154 | en_US |
dc.identifier.eissn | 2772-9508 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | English | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
crisitem.author.dept | College of Life Sciences | - |
crisitem.author.dept | Department of Food Science | - |
crisitem.author.dept | National Taiwan Ocean University,NTOU | - |
crisitem.author.orcid | 0000-0001-5486-7265 | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | College of Life Sciences | - |
顯示於: | 食品科學系 |
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