http://scholars.ntou.edu.tw/handle/123456789/8948
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Liu, Shing-Hwa | en_US |
dc.contributor.author | Chiu, Chen-Yuan | en_US |
dc.contributor.author | Wang, Lou-Pin | en_US |
dc.contributor.author | Chiang, Meng-Tsan | en_US |
dc.date.accessioned | 2020-11-20T11:53:25Z | - |
dc.date.available | 2020-11-20T11:53:25Z | - |
dc.date.issued | 2019-06 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.uri | http://scholars.ntou.edu.tw/handle/123456789/8948 | - |
dc.description.abstract | Obesity is known to cause skeletal muscle wasting. This study investigated the effect and the possible mechanism of fish oil on skeletal muscle wasting in an obese rat model. High-fat (HF) diets were applied to induce the defects of lipid metabolism in male Sprague-Dawley rats with or without substitution of omega-3 fatty acids-enriched fish oil (FO, 5%) for eight weeks. Diets supplemented with 5% FO showed a significant decrease in the final body weight compared to HF diet-fed rats. The decreased soleus muscle weights in HF diet-fed rats could be improved by FO substitution. The decreased myosin heavy chain (a muscle thick filament protein) and increased FOXO3A and Atrogin-1 (muscle atrophy-related proteins) protein expressions in soleus muscles of HF diet-fed rats could also be reversed by FO substitution. FO substitution could also significantly activate adenosine monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation, peroxisome-proliferator-activated receptor-gamma (PPAR gamma) coactivator 1 alpha (PGC-1 alpha), and PPAR gamma protein expression and lipoprotein lipase (LPL) mRNA expression in soleus muscles of HF diet-fed rats. These results suggest that substitution of FO exerts a beneficial improvement in the imbalance of lipid and muscle metabolisms in obesity. AMPK/PGC-1 alpha signaling may play an important role in FO-prevented obesity-induced muscle wasting. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | MDPI | en_US |
dc.relation.ispartof | MAR DRUGS | en_US |
dc.subject | DIET-INDUCED OBESITY | en_US |
dc.subject | INSULIN-RESISTANCE | en_US |
dc.subject | MESSENGER-RNA | en_US |
dc.subject | LIPOPROTEIN-LIPASE | en_US |
dc.subject | CREATINE SUPPLEMENTATION | en_US |
dc.subject | DOCOSAHEXAENOIC ACID | en_US |
dc.subject | ATROPHY | en_US |
dc.subject | MASS | en_US |
dc.subject | MICE | en_US |
dc.subject | RATS | en_US |
dc.title | Omega-3 Fatty Acids-Enriched Fish Oil Activates AMPK/PGC-1 alpha Signaling and Prevents Obesity-Related Skeletal Muscle Wasting | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.3390/md17060380 | - |
dc.identifier.isi | WOS:000475305700069 | - |
dc.identifier.url | <Go to ISI>://WOS:000475305700069 | |
dc.relation.journalvolume | 17 | en_US |
dc.relation.journalissue | 6 | en_US |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en_US | - |
crisitem.author.dept | College of Life Sciences | - |
crisitem.author.dept | Department of Food Science | - |
crisitem.author.dept | National Taiwan Ocean University,NTOU | - |
crisitem.author.orcid | 0000-0003-3481-7505 | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | College of Life Sciences | - |
顯示於: | 食品科學系 02 ZERO HUNGER 03 GOOD HEALTH AND WELL-BEING |
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