http://scholars.ntou.edu.tw/handle/123456789/9083
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Liu, Yu-Ming | en_US |
dc.contributor.author | Wu, Tsung-Han | en_US |
dc.contributor.author | Chiu, Yi-Han | en_US |
dc.contributor.author | Wang, Hang | en_US |
dc.contributor.author | Li, Tsung-Lin | en_US |
dc.contributor.author | Hsia, Simon | en_US |
dc.contributor.author | Chan, Yi-Lin | en_US |
dc.contributor.author | Wu, Chang-Jer | en_US |
dc.date.accessioned | 2020-11-20T12:05:17Z | - |
dc.date.available | 2020-11-20T12:05:17Z | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 2072-6694 | - |
dc.identifier.uri | http://scholars.ntou.edu.tw/handle/123456789/9083 | - |
dc.description.abstract | Simple Summary The supplement of TNuF, a total nutrition formula, before cancer diagnosis significantly enhanced the anticancer effect of radiotherapy against primary tumor and lung metastasis in tumor-bearing mice. Meanwhile, TNuF improved cancer related sarcopenia. We supposed that these benefits are related to the regulations of cell proliferation, angiogenesis, and immunity in tumor microenvironment. (1)Background: Radiotherapy (RT) is one of the major treatments for non-small cell lung cancer, but RT-associated toxicities usually impede its anticancer effect. Nutrient supplementation has been applied for cancer prevention or a complementary measure to anticancer therapy. Here, we explored the influence of total nutrition supplementation before and after cancer occurrence on the anticancer benefit and side effects of RT. (2)Methods: C57BL/6JNarl mice were inoculated with Lewis lung carcinoma cells and then treated with radiotherapy. TNuF, a total nutrition formula, was prescribed by oral gavage. In the preventive groups, TNuF supplementation started from seven days before tumor inoculation. In the complementary groups, TNuF supplementation began after tumor inoculation. (3)Results: TNuF successfully enhanced the anticancer effect of RT against primary tumor and lung metastasis. Additionally, the complementary supplement improved the high serum TNF-alpha level and the wasting of sartorius muscle in mice receiving RT. In histologic and molecular analysis, TNuF was observed to modulate EGFR, apoptosis, and VEGF and PD-1/PD-L1 pathways. Furthermore, the anticancer benefit of the preventive supplement was comparable to that of the complementary administration. (4)Conclusions: Our results demonstrated that the prescription of the TNuF total nutrition formula before and after cancer diagnosis attains similar benefits in testing subjects with typical anticancer RT. TNuF is also a potential sensitizer to anti-PD-1 immune therapy. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | MDPI | en_US |
dc.relation.ispartof | CANCERS | en_US |
dc.subject | GROWTH-FACTOR RECEPTOR | en_US |
dc.subject | PATHWAYS DOWNSTREAM | en_US |
dc.subject | PD-L1 EXPRESSION | en_US |
dc.subject | TUMOR | en_US |
dc.subject | RADIATION | en_US |
dc.subject | PATIENT | en_US |
dc.subject | HEAD | en_US |
dc.subject | APOPTOSIS | en_US |
dc.subject | CELLS | en_US |
dc.subject | ANGIOGENESIS | en_US |
dc.title | Positive Effects of Preventive Nutrition Supplement on Anticancer Radiotherapy in Lung Cancer Bearing Mice | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.3390/cancers12092445 | - |
dc.identifier.isi | WOS:000579920000001 | - |
dc.identifier.url | <Go to ISI>://WOS:000579920000001 | |
dc.relation.journalvolume | 12 | en_US |
dc.relation.journalissue | 9 | en_US |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en_US | - |
crisitem.author.dept | College of Life Sciences | - |
crisitem.author.dept | Department of Food Science | - |
crisitem.author.dept | National Taiwan Ocean University,NTOU | - |
crisitem.author.dept | Institute of Food Safety and Risk Management | - |
crisitem.author.dept | Bachelor Degree Program in Marine Biotechnology | - |
crisitem.author.dept | Center of Excellence for the Oceans | - |
crisitem.author.dept | Doctoral Degree Program in Marine Biotechnology | - |
crisitem.author.dept | Master Program of Food Satfety Management | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | College of Life Sciences | - |
crisitem.author.parentorg | College of Life Sciences | - |
crisitem.author.parentorg | College of Life Sciences | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | College of Life Sciences | - |
crisitem.author.parentorg | College of Life Sciences | - |
顯示於: | 食品科學系 03 GOOD HEALTH AND WELL-BEING |
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