http://scholars.ntou.edu.tw/handle/123456789/9091
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Tai, Cheng-Jeng | en_US |
dc.contributor.author | Wang, Hang | en_US |
dc.contributor.author | Wang, Chien-Kai | en_US |
dc.contributor.author | Tai, Chen-Jei | en_US |
dc.contributor.author | Huang, Ming-Te | en_US |
dc.contributor.author | Chih-Hsiung Wu | en_US |
dc.contributor.author | Chen, Ray-Jade | en_US |
dc.contributor.author | Kuo, Li-Jen | en_US |
dc.contributor.author | Wei, Po-Lei | en_US |
dc.contributor.author | Chang, Yu-Jia | en_US |
dc.contributor.author | Chang, Chun-Chao | en_US |
dc.contributor.author | Chiou, Hung-Yi | en_US |
dc.contributor.author | Chang-Jer Wu | en_US |
dc.date.accessioned | 2020-11-20T12:05:17Z | - |
dc.date.available | 2020-11-20T12:05:17Z | - |
dc.date.issued | 2017-05 | - |
dc.identifier.issn | 1591-8890 | - |
dc.identifier.uri | http://scholars.ntou.edu.tw/handle/123456789/9091 | - |
dc.description.abstract | Pancreatic cancer remains the fourth leading cause of cancer-related death in the USA with a 5-year survival rate of 5 %. The effects of epidermal growth factor receptor and vascular endothelial growth factor A blockade with chemotherapy on pancreatic tumor growth were examined. Mice bearing human PANC-1 cell xenografts were divided into three groups: T-CR (gemcitabine, cisplatin, and 5-fluorouracil), T-TR (cetuximab, bevacizumab, gemcitabine, cisplatin, and 5-fluorouracil), and vehicle control (T). The therapies were administered via intraperitoneal injections every 4 days for seven cycles from 7 weeks after cancer cell implantation. Mice treated with T-TR had significant reductions in tumor weight as compared to the control group (p < 0.05). Although mice in the T-CR group experienced a significant reduction in body weight gain, serum albumin, and gastrocnemius muscle mass (p < 0.05), no such reductions were observed in the T-TR group. Mice treated with T-TR had slightly increased CD11c(+) DC and CD49b(+) NK cell levels in the spleen (p < 0.05) and significantly lower tumor VEGF expression (p < 0.05). Tumor carcinoembryonic antigen expression was significantly reduced in both treatment groups (p < 0.05). Thus, addition of bevacizumab and cetuximab to gemcitabine, cisplatin, and fluorouracil may represent an effective treatment option for pancreatic cancer that warrants further study. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | SPRINGER-VERLAG ITALIA SRL | en_US |
dc.relation.ispartof | CLIN EXP MED | en_US |
dc.subject | GROWTH-FACTOR RECEPTOR | en_US |
dc.subject | PLUS GEMCITABINE | en_US |
dc.subject | 1ST-LINE THERAPY | en_US |
dc.subject | PHASE-III | en_US |
dc.subject | COMBINATION | en_US |
dc.subject | CARCINOMA | en_US |
dc.subject | TRIAL | en_US |
dc.subject | BLOCKADE | en_US |
dc.subject | SURVIVAL | en_US |
dc.title | Bevacizumab and cetuximab with conventional chemotherapy reduced pancreatic tumor weight in mouse pancreatic cancer xenografts | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.1007/s10238-016-0409-2 | - |
dc.identifier.isi | WOS:000400071200002 | - |
dc.identifier.url | <Go to ISI>://WOS:000400071200002 | - |
dc.relation.journalvolume | 17 | en_US |
dc.relation.journalissue | 2 | en_US |
dc.relation.pages | 141-150 | en_US |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | College of Life Sciences | - |
crisitem.author.dept | Department of Food Science | - |
crisitem.author.dept | National Taiwan Ocean University,NTOU | - |
crisitem.author.dept | Institute of Food Safety and Risk Management | - |
crisitem.author.dept | Bachelor Degree Program in Marine Biotechnology | - |
crisitem.author.dept | Center of Excellence for the Oceans | - |
crisitem.author.dept | Doctoral Degree Program in Marine Biotechnology | - |
crisitem.author.dept | Master Program of Food Satfety Management | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | College of Life Sciences | - |
crisitem.author.parentorg | College of Life Sciences | - |
crisitem.author.parentorg | College of Life Sciences | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | College of Life Sciences | - |
crisitem.author.parentorg | College of Life Sciences | - |
顯示於: | 食品科學系 03 GOOD HEALTH AND WELL-BEING |
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