http://scholars.ntou.edu.tw/handle/123456789/9091
標題: | Bevacizumab and cetuximab with conventional chemotherapy reduced pancreatic tumor weight in mouse pancreatic cancer xenografts | 作者: | Tai, Cheng-Jeng Wang, Hang Wang, Chien-Kai Tai, Chen-Jei Huang, Ming-Te Chih-Hsiung Wu Chen, Ray-Jade Kuo, Li-Jen Wei, Po-Lei Chang, Yu-Jia Chang, Chun-Chao Chiou, Hung-Yi Chang-Jer Wu |
關鍵字: | GROWTH-FACTOR RECEPTOR;PLUS GEMCITABINE;1ST-LINE THERAPY;PHASE-III;COMBINATION;CARCINOMA;TRIAL;BLOCKADE;SURVIVAL | 公開日期: | 五月-2017 | 出版社: | SPRINGER-VERLAG ITALIA SRL | 卷: | 17 | 期: | 2 | 起(迄)頁: | 141-150 | 來源出版物: | CLIN EXP MED | 摘要: | Pancreatic cancer remains the fourth leading cause of cancer-related death in the USA with a 5-year survival rate of 5 %. The effects of epidermal growth factor receptor and vascular endothelial growth factor A blockade with chemotherapy on pancreatic tumor growth were examined. Mice bearing human PANC-1 cell xenografts were divided into three groups: T-CR (gemcitabine, cisplatin, and 5-fluorouracil), T-TR (cetuximab, bevacizumab, gemcitabine, cisplatin, and 5-fluorouracil), and vehicle control (T). The therapies were administered via intraperitoneal injections every 4 days for seven cycles from 7 weeks after cancer cell implantation. Mice treated with T-TR had significant reductions in tumor weight as compared to the control group (p < 0.05). Although mice in the T-CR group experienced a significant reduction in body weight gain, serum albumin, and gastrocnemius muscle mass (p < 0.05), no such reductions were observed in the T-TR group. Mice treated with T-TR had slightly increased CD11c(+) DC and CD49b(+) NK cell levels in the spleen (p < 0.05) and significantly lower tumor VEGF expression (p < 0.05). Tumor carcinoembryonic antigen expression was significantly reduced in both treatment groups (p < 0.05). Thus, addition of bevacizumab and cetuximab to gemcitabine, cisplatin, and fluorouracil may represent an effective treatment option for pancreatic cancer that warrants further study. |
URI: | http://scholars.ntou.edu.tw/handle/123456789/9091 | ISSN: | 1591-8890 | DOI: | 10.1007/s10238-016-0409-2 |
顯示於: | 食品科學系 03 GOOD HEALTH AND WELL-BEING |
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